BGAP Study:
Brains, Genes, And Puberty

A study of Klinefelter syndrome and male adolescent neurodevelopment

We are looking for boys and young teens, ages 8-13, who either have confirmed Klinefelter syndrome (47, XXY) or are typically developing. This NIH funded project is designed to improve our understanding of brain and behavioral growth in boys during a critical time in their development. This is a longitudinal study, requiring a total of four annual study visits. Each visit consists of two (2-8 hour) days.

Participation involves a 2 day evaluation including:

  • Comprehensive physical, cognitive and behavioral evaluations
  • Brain imaging with MRI. Scans are safe, non-invasive, and do not involve X-rays. They are primarily used to look at the structures of the brain. However, because MRIs involve magnets, we cannot include anyone with metal in their bodies, like braces or other metal implants.

Inclusion criteria for participation – child must be:

  • Between 8-13 years old
  • Male

Potential benefits of participating:

  • Information from research behavioral and cognitive assessment, with a research report of the assessment results
  • Flight/hotel/ground transportation costs covered for the participating child and one care-giver/parent
  • Families will receive an honorarium of up to $100 for their participation

For more information or to enroll:


For general information about participant rights, contact 1-866-680-2906