The Human Brain Project

The CIBSR was one of the original funded sites for Phase I of the Human Brain Project, a multi-center, multi-NIH Institute supported research program designed to promote the development of innovative software, methodology and advanced informatics for the next decade of neuroscience research. This Program supported neuroinformatics research and development of cutting-edge computer-based tools and approaches to acquire, store, manipulate, analyze, integrate, synthesize, disseminate and utilize information about the brain and behavior. The research aims of the CIBSR Human Brain Project fell into in three principal areas:

• Ongoing development of advanced software modules for quantitative image analysis.

• Determination of the reliability and validity of the methods and algorithms comprising these modules.

• Evaluation of the utility of this software in pilot imaging studies of normal pediatric controls and unique pediatric patient groups with homogeneous genetic or neurobiological causes of neurobehavioral dysfunction.

Software Development

Creation of the software program BrainImageJava included development and validation of new interactive procedures for MRI quantification: e.g., semi-automated corpus callosum segmentation, methods for correction of inhomogeneity, single and multi-spectral fuzzy segmentation algorithms, a skull stripping method for rapid brain isolation in SPGR volumetric scans, and implementation of a Talairach-based stereotaxic parcellation scheme with 3D image datasets. The last version of the software included multiplatform capability, volume visualization and advanced image analysis tools.


Highlights of BrainImageJava Capabilities